Giant cell angiofibroma or localized periorbital lymphedema?
Identifieur interne : 003B41 ( Main/Exploration ); précédent : 003B40; suivant : 003B42Giant cell angiofibroma or localized periorbital lymphedema?
Auteurs : Michael C. Lynch [États-Unis] ; Catherine G. Chung [États-Unis] ; Charles S. Specht [États-Unis] ; Michael Wilkinson [États-Unis] ; Loren E. Clarke [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2013-12.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Angiofibrome, Cellules géantes, Lymphoedème, Tumeurs cutanées, Tumeurs de l'oeil.
- Adulte d'âge moyen, Diagnostic différentiel, Femelle, Humains.
English descriptors
- KwdEn :
- MESH :
- pathology : Angiofibroma, Eye Neoplasms, Giant Cells, Lymphedema, Skin Neoplasms.
- Diagnosis, Differential, Female, Humans, Middle Aged.
Abstract
Giant cell angiofibroma represents a rare soft tissue neoplasm with a predilection for the orbit. We recently encountered a mass removed from the lower eyelid of a 56‐year‐old female that histopathologically resembled giant cell angiofibroma. The process consisted of haphazardly arranged CD34‐positive spindled and multinucleated cells within an edematous, densely vascular stroma. However, the patient had recently undergone laryngectomy and radiotherapy for a laryngeal squamous cell carcinoma. A similar mass had arisen on the contralateral eyelid, and both had developed several months post‐therapy. Lymphedema of the orbit can present as tumor‐like nodules and in some cases may share histopathologic features purported to be characteristic of giant cell angiofibroma. A relationship between giant cell angiofibroma and lymphedema has not been established, but our case suggests there may be one. The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis.
Url:
DOI: 10.1111/cup.12225
Affiliations:
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Lynch</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The Penn State Hershey Medical Center, PA, Hershey</wicri:regionArea><wicri:noRegion>Hershey</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Chung, Catherine G" sort="Chung, Catherine G" uniqKey="Chung C" first="Catherine G." last="Chung">Catherine G. Chung</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The Penn State Hershey Medical Center, PA, Hershey</wicri:regionArea><wicri:noRegion>Hershey</wicri:noRegion></affiliation></author><author><name sortKey="Specht, Charles S" sort="Specht, Charles S" uniqKey="Specht C" first="Charles S." last="Specht">Charles S. 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Clarke</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The Penn State Hershey Medical Center, PA, Hershey</wicri:regionArea><wicri:noRegion>Hershey</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1059">1059</biblScope><biblScope unit="page" to="1062">1062</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-12">2013-12</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiofibroma (pathology)</term><term>Diagnosis, Differential</term><term>Eye Neoplasms (pathology)</term><term>Female</term><term>Giant Cells (pathology)</term><term>Humans</term><term>Lymphedema (pathology)</term><term>Middle Aged</term><term>Skin Neoplasms (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Angiofibrome (anatomopathologie)</term><term>Cellules géantes (anatomopathologie)</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Tumeurs cutanées (anatomopathologie)</term><term>Tumeurs de l'oeil (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Angiofibrome</term><term>Cellules géantes</term><term>Lymphoedème</term><term>Tumeurs cutanées</term><term>Tumeurs de l'oeil</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Angiofibroma</term><term>Eye Neoplasms</term><term>Giant Cells</term><term>Lymphedema</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Giant cell angiofibroma represents a rare soft tissue neoplasm with a predilection for the orbit. We recently encountered a mass removed from the lower eyelid of a 56‐year‐old female that histopathologically resembled giant cell angiofibroma. The process consisted of haphazardly arranged CD34‐positive spindled and multinucleated cells within an edematous, densely vascular stroma. However, the patient had recently undergone laryngectomy and radiotherapy for a laryngeal squamous cell carcinoma. A similar mass had arisen on the contralateral eyelid, and both had developed several months post‐therapy. Lymphedema of the orbit can present as tumor‐like nodules and in some cases may share histopathologic features purported to be characteristic of giant cell angiofibroma. A relationship between giant cell angiofibroma and lymphedema has not been established, but our case suggests there may be one. The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Lynch, Michael C" sort="Lynch, Michael C" uniqKey="Lynch M" first="Michael C." last="Lynch">Michael C. Lynch</name></noRegion><name sortKey="Chung, Catherine G" sort="Chung, Catherine G" uniqKey="Chung C" first="Catherine G." last="Chung">Catherine G. Chung</name><name sortKey="Clarke, Loren E" sort="Clarke, Loren E" uniqKey="Clarke L" first="Loren E." last="Clarke">Loren E. Clarke</name><name sortKey="Lynch, Michael C" sort="Lynch, Michael C" uniqKey="Lynch M" first="Michael C." last="Lynch">Michael C. Lynch</name><name sortKey="Specht, Charles S" sort="Specht, Charles S" uniqKey="Specht C" first="Charles S." last="Specht">Charles S. Specht</name><name sortKey="Specht, Charles S" sort="Specht, Charles S" uniqKey="Specht C" first="Charles S." last="Specht">Charles S. Specht</name><name sortKey="Wilkinson, Michael" sort="Wilkinson, Michael" uniqKey="Wilkinson M" first="Michael" last="Wilkinson">Michael Wilkinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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